Alteration Of Thiol-Disulphide Homeostasis In Chronic Otitis Media
| Autor: | Muhammed Ayral, Serdar Ferit Toprak, Serkan Dedeoğlu, İlhan Sabancılar, Hakan Temiz |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Dicle Medical Journal, Vol 48, Iss 1, Pp 197-204 (2021) |
| ISSN: | 1308-9889 1300-2945 |
| Popis: | Objectives: We aimed to invastigate dynamic thiol-disulfide homeostasis, a new oxidative stress marker of oxidant and antioxidant balance, serum native thiol, total thiol and disulfide levels in patients with chronic otitis media in this study. Method: A total of 59 patients with chronic otitis media between the ages of 18-60 and 59 healthy volunteers in the same age group were included in this study whose diagnosis was confirmed by otomicroscopic examination and audiological tests.The control group consisted of 59 healthy individuals who were asymptomatic with no medical history and normal physical examination. Pure tone audiometry and computed tomography of temporal bone were examined in all patients. Patients showing granulation tissue in mastoid cells and soft tissue density in the middle ear on computed tomography were selected for the study. Thiol-disulfide homeostasis parameters were measured by the spectrophotometric method using commercially avaible kits (Rel Assay Diagnostics, Turkey). Results: Half of the 118 participants included in this study were cases and the other half constituted the control group. 74 (62,7%) of all participants included in the study were found to be women. The mean age of the case group was 42,03 ± 11,01; the average age of the control group was 41,47 ± 10,90. Various blood values and rates of the participants in the case and control groups were compared. Blood levels of native thiol (399,27 ± 41,57) and total thiol (411,30 ± 42,15) in the case group were determined as native thiol (422,13 ± 41,03) and total thiol (435,93 ± 44, 03) was significantly lower than the values of the control groups (p0.05). Conclusion: In conclusion, the present results obtained from this study indicated that dynamic thiol changes were significantly impaired in patients with chronic otitis media. Further clinical studies and observations are needed to find out how effective the addition of antioxidant therapy can be in the treatment of chronic otitis media, whether it will change the treatment modalities, or whether it can break the absolute dominance of surgery. |
| Databáze: | OpenAIRE |
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