| Popis: |
Objective: To explore the plasma endothelium inhibition and type 2 diabetes mellitus patients with Diabetic Nephropathy the correlation between risk and its predictive value. Methods: From January 2015 to January 2017, 202 cases of type 2 diabetes mellitus patients diagnosed and treated in our hospital were selected and divided into observation group and control group according to DN occurrence during follow-up, general data and blood biochemical indexes before treatment were compared between the two groups, Logistic regression was used to analyze independent risk factors of DN, and ROC curve was used to evaluate the predictive effectiveness of different indicators on DN occurrence. Results: A total of 35 developed DN In this study. The mean arterial pressure, HbA1c, UACR and endostatin in observation group were significantly higher than control group, GFR in observation group was significantly lower than control group, multivariate Logistic regression showed that GFR was an independent protective factor for DN, and HbA1c, UACR and endostatin were independent risk factors for DN, The best cut-off point for endostatin prediction of DN occurrence was 43.29 ng/mL, and the AUC was 0.890, significantly better than GFR, HbA1c and UACR, the sensitivity was 85.71%, significantly better than other indicators. Conclusions: Endostatin was significantly associated with DN risk in patients with type 2 diabetes mellitus and had good predictive efficacy. |
