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Objectives: The objective of this study was to investigate any differences between female undergraduate medical and non-medical students for: 1) prevalence and causes of perceived academic stress, and 2) changes in physical, mental, psychological and emotional health as well as life-style since starting college studies. Methods: A cross-sectional study was conducted at Dammam University, Dammam, Saudi Arabia, in January 2008. All 319 pre-clinical female medical students were included in the study and 297 non-medical students from the College of Applied Studies and Community Services (CASCS) were selected by stratified random sampling. The study instrument was a questionnaire on the “Influence of Studying on Students’ Health”. Results: More medical students (48.6%) reported being frequently stressed due to studies than CASCS students (38.7%, P |