| Autor: |
Canan KUŞ, Ezgi UĞURLU, Elçin D. ÖZDAMAR, Benay CAN-EKE |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Turkish Journal of Pharmaceutical Sciences, Vol 14, Iss 2, Pp 174-178 (2017) |
| ISSN: |
2148-6247 |
| Popis: |
Objectives: To synthesize and characterize 4-(substituted benzylidene)-2-(substituted phenyl)oxazol-5(4H)-one derivatives (E1-E10), and evaluate them for antioxidant activity. Materials and Methods: Required oxazole-5(4H)-one derivatives were synthesized in two steps to obtain novel hippuric acid derivatives (7-13); glycine and acylated appropriate benzoic acid derivatives were used and then, final compounds were obtained with condensation of 7-13 with appropriate benzaldehydes (E1-E10). These products were purified by column chromatography using ethyl acetate/n-hexane as eluent. All the compounds were unequivocally characterized using the combination of 1H and 13C-nuclear magnetic resonance, mass spectrometry (ESI-MS), and elemental analysis. The inhibition of lipid peroxidation and its effects on hepatic cytochrome P450-dependent ethoxyresorufin-O-deethylase (EROD) enzyme were determined in rats in vitro. Results: The most active analogue on the microsomal EROD activity was E3 which inhibited the microsomal EROD activity (89%) and was similarly better than that of the specific inhibitor caffeine (85%) at 10-3 M concentration. Conclusion: The findings of this study indicate that the synthesized compounds, such as E3, display significant antioxidant activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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