Fixed-dose combination of enalapril maleate and hydrochlorothiazide: potential in achieving target blood pressure among hypertensive patients

Autor:	S. V. Nedogoda, T. A. Chalyabi, U. A. Brel, G. G. Mazina, E. V. Podolskaya, D. A. Zaremba
Jazyk:	ruština
Rok vydání:	2008
Předmět:	arterial hypertension RC666-701 target blood pressure level achievement Diseases of the circulatory (Cardiovascular) system fixed-dose and arbitrary combinations of antihypertensive medications
Zdroj:	Кардиоваскулярная терапия и профилактика, Vol 7, Iss 6, Pp 21-27 (2008)
ISSN:	2619-0125 1728-8800
Popis:	Aim. To assess the effectiveness of fixed-dose combination of enalapril maleate (20 mg) and hydrochlorothiazide (12,5 mg) - Enap NL 20, comparing to arbitrary combinations of two antihypertensive medications (АНМ), in patients with Stage I-III arterial hypertension (АН) and resistance to previous antihypertensive monotherapy.Material and methods. In 200 patients with high-risk АН and resistance to previous antihypertensive therapy, effectiveness of fixed-dose combination Enap NL 20 and arbitrary АНМ combinations was compared in an open, randomized, controlled parallel-group study Therapy effectiveness was assessed by 24-hour blood pressure monitoring (BPM).Results. Fixed-dose combination Enap NL 20 was more effective than arbitrary combinations of two АНМ for systolic and diastolic BP (SBP, DBP) reduction: -17,3% vs. -10,3% and -13% vs. -5,3%, respectively (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doajarticles::4330d790a411734ceebc046b987346ba https://cardiovascular.elpub.ru/jour/article/view/1628 Zobrazit plný text záznamu