| Popis: |
Objective: To judge the value of serum miRNAs contents for degree of lesions and prognosis of patients with acute myocardial infarction. Methods: A total of 52 cases of patients with acute myocardial infarction were selected as AMI group, 52 cases of healthy volunteers were selected as control group, and serum was collected to detect the contents of miRNAs, inflammatory factors and protease molecules. Results: Serum miR-1, miR-22, miR133a and miR133b contents of AMI group were higher than those of control group, and miR-147, miR-214 and miR328 contents were lower than those of control group; the more the number of coronary lesions in patients with AMI, the higher the serum miR-1, miR-22, miR133a and miR133b contents, and the lower the miR-147, miR-214 and miR328 contents; serum hs-CRP, TNF-α, MCP-1, IL-6 and IL-18 contents of AMI group were significantly higher than those of control group; results of the correlation analysis between inflammatory factor contents and miRNAs contents were as follows: hs-CRP, TNF-α, MCP-1, IL-6, IL-18, MMP1, MMP2, MMP3, MMP8, MMP9, MMP14 and ADAMTS-1 contents were negatively correlated with miR-1, miR-22, miR133a and miR133b contents, and positively correlated with miR-147, miR-214 and miR328 contents. Conclusion: Serum miR-1, miR-22, miR133a, miR133b, miR- 147, miR-214 and miR328 contents are abnormal in patients with acute myocardial infarction, and miRNAs may be involved in the occurrence and development of the disease through regulating the expression of inflammatory factors and protease molecules. |
