| Autor: |
Stella Maris Martínez, María Cristina Tarrés, Silvana Marisa Montenegro, Stella Maris Daniele, Juan Carlos Picena |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Electronic Journal of Biomedicine, Vol 2007, Iss 3, Pp 29-39 (2007) |
| Popis: |
Non-alcoholic fatty liver is a common disease closely related to the increasing prevalence of obesity and type 2 diabetes in the general population. The eSS rats display a non obese type 2 diabetic syndrome with an insulin resistant state characterized by hyperglycaemia, hypertriglyceridemia and hyperinsulinemia. In 12 month-old eSS males glycaemia, fructosamine, triglyceridemia and reactive species to oxygen were evaluated, and the hepatic histology was studied. Increased basal glycaemia and fructosamine values correlate directly with those of lipid peroxidation and inversely with antioxidant values. Diffuse steatosis was detected. Cytoplasmatic PAS positive granularity decreased towards the center of the lobule. Binucleated hepatocytes were observed, as well as regular mobilization of Kupffer cells. The pattern of lipidic deposits in eSS rat's hepatocytes was similar to the one observed in biopsies of type 2 diabetic patients. As eSS displays a diabetic syndrome without obesity, these findings suggest the capacity of increased levels of oxidative stress to induce hepatic steatosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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