| Popis: |
Objective: To evaluate the tumor malignancy in patients with HER-2 overexpression breast cancer after TCH and TAC neoadjuvant chemotherapy. Methods: A total of 86 cases of patients with HER-2 overexpression breast cancer were randomly divided into observation group and control group (n=43), control group received TAC neoadjuvant chemotherapy, observation group received TCH neoadjuvant chemotherapy, and then the differences in mRNA expression levels of invasion-related indicators and autophagy-related genes in tumor tissue as well as the levels of serum tumor markers and angiogenesis molecules before and after treatment were compared between two groups of patients. Results: After observation group received TCH neoadjuvant chemotherapy, the mRNA expression levels of invasion-promoting molecules OPN, CD44v6 and CD10 in breast cancer tissue were lower than those of control group, mRNA expression levels of invasion-inhibiting molecules TIMP-2 and TIMP-3 were higher than those of control group, and mRNA expression levels of apoptosis-related genes ATG2B, ATG4D, ATG9B and LC3-II as well as LC3-II/LC3-I ratio were significantly higher than those of control group; 1 week after treatment, serum CEA, CA15-3, CA125, VEGF and bFGF levels of observation group were lower than those of control group. Conclusion: TCH neoadjuvant chemotherapy can significantly reduce the tumor malignancy in patients with HER-2 overexpression breast cancer, and is of positive significance in optimizing the longterm treatment outcome. |
