Anti-HSV-1 activity in vitro of extracellular polysaccharides purification of Paecilomyces lilacinus on isolated from Hainan mangrove

Autor: Yong-Xia Wang, Yan-Ni Huang, Guo-Jun Li, Ting-Ting Ge, Cheng Chang, Hua Pei, Wen Yang, Ying-Zi Lin
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Hainan Medical University, Vol 22, Iss 19, Pp 1-4 (2016)
ISSN: 1007-1237
Popis: Objective: To explore the antiviral activity on HSV-1 of the extracellular polysaccharides (EPS) purification of Paecilomyces lilacinus (P. lilacinus) isolated from mangrove in Hainan province. Methods: The toxicity of the EPS purification on Vero cells and its anti-HSV-1 activity were assessed by cytopathic effect(CPE) and MTT assay. The Vero cells survival rates, HSV-1 inhibition rates by the purification and virus titer were calculated. Results: The purification showed little cytotoxic effect on Vero with a CC50 value of 735.49 µg/mL. It could inhibit HSV-1 absorption on Vero cells, and there was a significant difference (P
Databáze: OpenAIRE