Endothelial condition and hemostasis in acute leukemia
| Autor: | Lyudmila Nikolaevna Tarasova, Ol'ga Yur'evna Skol'skaya, Sof'ya Gennad'evna Vladimirova, L N Tarasova, O Yu Skolskaya, S G Vladimirova |
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| Jazyk: | ruština |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 83, Iss 7, Pp 74-78 (2011) |
| ISSN: | 2309-5342 0040-3660 |
| Popis: | The review presents modern conceptions of disturbances in endothelial lining of the vessels and plasmic hemostasis in patients with acute leukemia; different mechanisms of coagulation disorders in acute leukemia: effects of leukemic cells containing procoagulants, fibrinolytic and antifibrinolytic substances, of intensive chemotherapy and inflammation. All these impacts impair endothelial cells and trigger plasmic coagulation cascade; the initiator of coagulation is a tissue factor. Mechanisms of this process and statistics of thrombohemorrhagic complications in different variants of acute leukemia are outlined. |
| Databáze: | OpenAIRE |
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