Severe anemia affects both splenectomized and non-splenectomized Plasmodium falciparum-infected Aotus infulatus monkeys
| Autor: | Carvalho Leonardo J de Moura, Alves Francisco Acácio, Oliveira Salma Gomes de, Rio do Valle Rodrigo del, Fernandes Andréa A Morais, Muniz José A Pereira Carneiro, Daniel-Ribeiro Claudio T |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 98, Iss 5, Pp 679-686 (2003) |
| ISSN: | 1678-8060 0074-0276 |
| Popis: | Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection. |
| Databáze: | OpenAIRE |
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