Popis: |
Objective: To observe the influence of general anesthesia combined with epidural anesthesia on adrenal cortex, stress factors and immunologic function in patients with lung cancer. Methods: A total of 60 patients with lung cancer were randomly divided into two groups: observation group (30 cases) and control group (30 cases). Observation group: general anesthesia combined with epidural anesthesia; control group: patients were treated only by general anesthesia. Recording and comparing the levels of Ang-Ⅱ, Cor, AD, MDA, GC, ALDO, 17-OH, 17-KS and immunologic function before and after treatment. Results: (1) Before treatment, there was no statistically significant difference in the serum Ang-Ⅱ, Cor, AD, MDA, GC, ALDO, 17- OH, 17-KS levels between the two groups. After treatment, the serum Ang-Ⅱ, Cor, AD, MDA, GC, ALDO, 17-OH, 17-KS levels of the two groups were significantly lower than those of the same group before treatment, and those levels of observation group were significantly better than the control group, there was significant difference between the two groups. (2) Before treatment, there was no statistically significant difference in CD4+, CD8+, CD4+/CD8+ between the two groups. After treatment, the CD4+, CD4+/CD8+ of the two groups were significantly lower than those of the same group before treatment, the CD8+ of the two groups were significantly higher, and those levels of observation group were significantly better than the control group, there was significant difference between the two groups. Conclusion: General anesthesia combined with epidural anesthesia for patients with lung cancer can perfect the levels of serum adrenal cortical hormone, stress factors and be beneficial to protect their immunologic function. |