Lipid profile and atherogenic predictor indices of albino rabbits administered coconut water as antidote to paracetamol overdose
| Autor: | Chidi Uzoma Igwe, Callistus Izunna Iheme, Chinwe Slyvanus Alisi, Linus Ahuwaraeze Nwaogu, Chiedozie Onyejiaka Ibegbulem, Aloysius Chinedu Ene |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of Coastal Life Medicine, Vol 4, Iss 12, Pp 974-979 (2016) |
| ISSN: | 2309-6152 2309-5288 |
| Popis: | Objective: To investigate the effects of coconut water intake on lipid profile and atherogenic predictor indices of albino rabbits overdosed with paracetamol using standard methods. Methods: Thirty-five albino rabbits weighing between 800–1200 g and aged between 2 and 3 months, were divided into 7 groups (I–VII) of 5 animals each. Groups I, II and III were orally administered distilled water (20 mL/kg body weight), coconut water (20 mL/kg body weight) and paracetamol (1000 mg/kg body weight) respectively, for 7 days. Groups IV and V were administered coconut water (20 mL/kg body weight) and silymarin (35 mg/kg body weight), respectively, for 6 days, then paracetamol (1000 mg/kg body weight) on the 7th day. Groups VI and VII were administered distilled water for 6 days, paracetamol on the 7th day, then coconut water and silymarin, respectively, after 3 h. Results: The results showed that paracetamol overdose significantly reduced (P < 0.05) the mean body weight of the animals, increased the concentrations of serum total cholesterol, triacylglycerol, very low density lipoprotein cholesterol, low density lipoprotein cholesterol and the atherogenic predictor indices but reduced the serum high density lipoprotein cholesterol concentration of the animals relative to the control. The observed changes in the lipid profile and atherogenic predictor indices were countered more by post- than pre-treatment with coconut water and silymarin. Conclusions: The results indicated that coconut water acted as an effective antidote to paracetamol overdose-induced lipid abnormality in animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|