| Popis: |
With the popularization of molecular targeted drugs, precision medicine is gradually applied in cancer field. It makes cancer diagnosis and treatment more specific and targeted by combining genetic information, diagnosis and treatment of individual disease together. Therefore, to seek markers that can real-timely monitor cancer status is very important. As a key pathway of precision treatment, liquid biopsy is usually defined as the simple tests quickly done in blood samples or other body fluids. In cancer patients, the objective of those tests is to detect samples obtained from the tumors. As a non-invasive diagnostic technique, liquid biopsy takes circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and exosomes as the biomarkers of cancer diagnosis, which not only avoids surgical biopsy and aspiration biopsy, but also extracts the tumor samples repeatedly, consequently convenient for doctors to establish gene expression profiles. This article mainly reviewed CTCs and ctDNA monitoring technologies as well as their application in precision medicine. |
