Evaluation of innate lymphoid cells, mucosal-associated invariant T cells and helper T cells in human autoimmune uveitis
| Autor: | Decker, Paul, Moulinet, Thomas, Jaussaud, Rolland, Cravat, Maxime, Corriger, Jérémy, De Carvalho-Bittencourt, Marcelo |
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| Přispěvatelé: | DE CARVALHO, MARCELO, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | 52nd Annual Meeting of the French Society for Immunology 52nd Annual Meeting of the French Society for Immunology, Nov 2019, Nantes, France |
| Popis: | International audience; Up to 50 % of uveitis are classified as « idiopathics ». Uveitis association with Th1 and Th17-mediated systemic inflammatory disorders-such as IBD and spondylarthritis-and immunosuppressive agents efficacy suggest underlying autoimmune mechanisms. Specific T cell responses to retinal antigens (IRBP and S-arrestin) have been identified in patients with idiopathic uveitis. A transgenic murine model of spontaneous autoimmune uveitis recently showed that specific retinal antigen T cells were initially activated in the intestine by microbiota extracts before they migrated and entered into the eye (1). Innate lymphoid cells (ILC) and mucosal-associated invariant T cells (MAIT) are innate immune cells recently discovered and particularly represented in mucosal tissues. These cells have never been evaluated in human uveitis. Objective : To study circulating ILC, MAIT and T lymphocytes in human autoimmune uveitis Elevation of Th17 cells in uveitis patients compared to controls at diagnosis patients controls. |
| Databáze: | OpenAIRE |
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