The protective effect of quercetin and it nanocrystal on anxiety-like behaviors induced by animal model of Alzheimer’s disease
| Autor: | Akbar Hajizadeh Moghaddam, Zare, M., Rostamian, S., Khanjani, S. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Medicinal Plants, Vol 16, Iss 62, Pp 158-168 (2017) Scopus-Elsevier |
| ISSN: | 2717-2058 |
| Popis: | The protective effect of quercetin and it nanocrystal on anxiety-like behaviors induced by animal model of Alzheimer’s disease Introduction: Alzheimer is a neurodegenerative disease which is characterized by progressive memory loss, diminished cognitive ability and behavioral disturbances such as anxiety-like behaviors. Quercetin is polyphenolic compound with antioxidant and neuroprotective effects. Objective: Purpose of this study is evaluated antianxiety effect of quercetin and its nanocrystal in model of Alzheimer’s disease. Methods: In present study, 49 male rats were divided into 7 groups: control (normal untreated rats), sham (received distilled water orally and saline intrcerebroventriculary), disease (received 10µg/rat STZ and distilled water) and disease treated with quercetin and its nanocrystal groups (received quercetin and its nanocrystal at doses of 10 and 25 mg/kg of body weight per day orally for four weeks after injection of STZ). Model of Alzheimerchr('39')s disease induced by intracerebroventicular injection of STZ (icv-STZ) at doses of 10µg/rat. Elevated plus maze (EPM) test was used to assess anxiety-like behaviors. Results: Results indicated that icv-STZ injection significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|