Serum antimüllerian hormone is not predictive of oocyte quality in vitro fertilization
| Autor: | Guerif, Fabrice, Lemseffer, M., Couet, M.L., Gervereau, O., Ract, V., Royère, Dominique |
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| Přispěvatelé: | Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Service de Médecine et Biologie de la Reproduction, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
endocrine system
endocrine system diseases urogenital system [SDV]Life Sciences [q-bio] female genital diseases and pregnancy complications HORMONE ANTIMÜLLERIENNE KIT ELISA RESERVE OVARIENNE GROSSESSE CLINIQUE AMH REPRODUCTION HUMAINE [INFO]Computer Science [cs] MATURITE OVOCYTAIRE QUALITE EMBRYONNAIRE |
| Zdroj: | Annales d'Endocrinologie Annales d'Endocrinologie, Elsevier Masson, 2009, 70 (4), pp.230-234. ⟨10.1016/j.ando.2009.03.007⟩ |
| ISSN: | 0003-4266 |
| Popis: | International audience; Objectives. - The assessment of the ovarian reserve is mandatory in women undergoing assisted reproduction. Antimullerian hormone (AMH) produced by granulosa cells from preantral and early antral follicles, is a promising indicator of ovarian reserve. However, few studies have evaluated the predictive value of AMH on oocyte quality. Material and methods. - A retrospective study was undertaken at the Bretonneau University Hospital of Tours. A total of 559 women undergoing in vitro fertilization treatment between January 2007 and December 2007 were included in the study. Serum AMH levels were determined by using an ultrasensitive ELISA test. Total number of oocytes, rate of mature oocytes, fertilization rate, embryo quality and clinical pregnancy rate were recorded. Results. - Serum AMH was significantly lower in groups of patients with few oocytes collected. However, serum AMH was not predictive of nuclear maturity of oocytes, fertilization rate and quality of early embryos. Additionally, low levels of AMH do not preclude clinical pregnancy, in in vitro fertilization. Conclusion. - At the moment, serum AMH is a relatively predictive indicator of the ovarian reserve, in terms of quantity but not in terms of quality. Moreover, it is still not possible to determine serum AMH cut-off value to predict clinical pregnancy in IVF programmes. (C) 2009 Elsevier Masson SAS. All rights reserved. |
| Databáze: | OpenAIRE |
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