Reactive and clonal thrombocytosis: Cytokines and acute phase reactants
| Autor: | Ljiljana Fodor-Alagić, Vladimir Stančić, Petar Gaćina, Dubravka Čaržavec, Vjeran Nikolić-Heitzler, Danijel Planinc, Krešimir Štambuk, Ivan Bonić, Boris Car, Miljenko Solter, Mira Vitezić-Misjak, Branko Bečejac, Velimir Altabas |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Thrombocytosis - classification
Thrombocytosis - etiology Thrombocytosis - blood Thrombocytosis - diagnosis Thrombocytosis-classification Thrombocytosis-etiology Thrombocytosis-blood Thrombocytosis-diagnosis Trombocitoza - klasifikacija Trombocitoza - etiologija Trombocitoza - krv Trombocitoza - dijagnostika |
| Zdroj: | Acta clinica Croatica Volume 43 Issue 1 |
| ISSN: | 0353-9466 1333-9451 |
| Popis: | Platelets are acute phase reactants that increase in response to various stimuli, including systemic infections, inflammatory conditions, bleeding, and tumors. This is called reactive or secondary thrombocytosis, which is a benign form of thrombocytosis. Clonal thrombocytosis is an unregulated abnormality of platelet production due to clonal expansion of bone marrow progenitor cells. Secondary thrombocytosis may be due to the overproduction of proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and IL-11, which occurs in chronic inflammatory, infectious and malignant states. The presence of elevated IL-1, IL-6, C-reactive protein and granulocyte-macrophage colony-stimulating factor in individuals with this condition suggests that these cytokines may be involved in reactive thrombocytosis. Trombociti su reaktanti akutne faze i njihov se broj povećava kao odgovor na različite podražaje, uključujući sistemske infekcije, upalna stanja, krvarenja i tumore. To se naziva reaktivnom ili sekundarnom trombocitozom, što je benigni oblik trombocitoze. Esencijalna trombocitoza je nenormalna proizvodnja trombocita uzrokovana klonskom ekspanzijom progenitorske stanice koštane srži. Sekundarna trombocitoza može biti uzrokovana prekomjernom proizvodnjom proupalnih citokina, kao što su interleukin 1 (IL-1), IL-6, IL-11, koji se javljaju u kroničnim upalnim, infektivnim i malignim stanjima. Prisutnost povišenih vrijednosti IL-1, IL-6, C-reaktivnog proteina i granulocitno-makrofagnog faktora stimulacije rasta u pojedinaca s ovim stanjem ukazuje kako bi ovi citokini mogli biti upleteni u reaktivnu trombocitozu. |
| Databáze: | OpenAIRE |
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