Colchicine-induced neuromyopathy in a patient with chronic renal failure: the role of clarithromycin

Autor: Velden, W. van der, Huussen, J., Laak, H.J. ter, Sevaux, R.G.L. de
Rok vydání: 2008
Předmět:
Zdroj: Netherlands Journal of Medicine, 66, 5, pp. 204-6
Netherlands Journal of Medicine, 66, 204-6
ISSN: 0300-2977
Popis: Item does not contain fulltext Neuromyopathy is a rare side effect of chronic colchicine therapy, most often occurring in patients with chronic renal failure. Drugs interacting with colchicine metabolism through CYP(3)A(4) and P-glycoprotein can accelerate accumulation and toxicity. We describe a case of an interaction between clarithromycin and colchicine resulting in acute neuromyopathy, and we conclude that combined use of macrolides and colchicine should be avoided.
Databáze: OpenAIRE