Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model
| Autor: | Bruce, Matthew R, Jones, Karen L, Vernon, Anthony C, Silverman, Jill L, Crawley, Jacqueline N, Ellegood, Jacob, Lerch, Jason P, Van de Water, Judy |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatric Psychiatry Animal Autism Spectrum Disorder Autism Intellectual and Developmental Disabilities (IDD) Psychology and Cognitive Sciences Neurosciences Brain Biological Sciences Autoimmune Disease Basic Behavioral and Social Science Medical and Health Sciences Brain Disorders Mice Epitopes Mental Health mental disorders Disease Models Behavioral and Social Science Animals Biomedical Imaging Female Autoantibodies |
| Zdroj: | Molecular psychiatry, vol 26, iss 12 |
| Popis: | Immunoglobulin G (IgG) autoantibodies reactive to fetal brain proteins in mothers of children with ASD have been described by several groups. To understand their pathologic significance, we developed a mouse model of maternal autoantibody related ASD (MAR-ASD) utilizing the peptide epitopes from human autoantibody reactivity patterns. Male and female offspring prenatally exposed to the salient maternal autoantibodies displayed robust deficits in social interactions and increased repetitive self-grooming behaviors as juveniles and adults. In the present study, neuroanatomical differences in adult MAR-ASD and control offspring were assessed via high-resolution ex vivo magnetic resonance imaging (MRI) at 6 months of age. Of interest, MAR-ASD mice displayed significantly larger total brain volume and of the 159 regions examined, 31 were found to differ significantly in absolute volume (mm3) at an FDR of |
| Databáze: | OpenAIRE |
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