Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis

Autor: Schouten, W E, Grooteman, M P, van Houte, A J, Schoorl, M, van Limbeek, J, Nubé, M J
Přispěvatelé: Nephrology, ACS - Diabetes & metabolism
Jazyk: angličtina
Rok vydání: 2000
Zdroj: Nephrology, Dialysis, Transplantation, 15(3), 379-84. Oxford University Press
Schouten, W E, Grooteman, M P, van Houte, A J, Schoorl, M, van Limbeek, J & Nubé, M J 2000, ' Effects of dialyser and dialysate on the acute phase reaction in clinical bicarbonate dialysis ', Nephrology, Dialysis, Transplantation, vol. 15, no. 3, pp. 379-84 .
ISSN: 0931-0509
Popis: BACKGROUND: In chronic haemodialysis (HD), morbidity may result from repetitive induction of the acute phase response, caused by a bioincompatible dialysis membrane and/or contaminated dialysate. In the present study, cytokine release (interleukin-6, IL-6) and subsequent production of acute phase proteins (C-reactive protein, CRP and secretory phospholipase A(2), sPLA(2)) were assessed to investigate whether the HD-induced acute phase reaction depends mainly on the type of membrane or on the sterility of the dialysate.METHODS: In 11 patients, IL-6, CRP and sPLA(2) levels were assessed in blood samples drawn before (t(0)), at the end (t(180)) and 24 h after the start of HD (t(1440)). All patients were dialysed on Cuprammonium (CU) and Polysulphon (PS) dialysers and seven patients underwent an additional HD session on CU plus a dialysate filter (CUf).RESULTS: IL-6 levels were increased significantly at t(180) compared with t(0) (PCONCLUSIONS: In contrast to PS, both CU and CUf resulted in elevated IL-6 plasma levels at the end of HD, compared with t(0), which correlated with increased CRP and sPLA(2) values 24 h later. Therefore, the type of membrane, rather than the bacterial quality of the dialysate, seems to be responsible for the induction of the acute phase response during clinical bicarbonate HD.
Databáze: OpenAIRE
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