Oxidation-induced spin probes in low-density lipoproteins

Autor:	Dubravka Krilov, Marta Žuvić-Butorac, Nataša Stojanović, Janko N. Herak
Jazyk:	angličtina
Rok vydání:	2004
Předmět:	mild oxidation spin trap PRIRODNE ZNANOSTI. Fizika. Atomska i molekulska fizika PBN lipids (amino acids peptides and proteins) free radicals LDL EPR spectroscopy NATURAL SCIENCES. Physics. Atomic and Molecular Physics
Zdroj:	Croatica Chemica Acta Volume 77 Issue 1-2
ISSN:	0011-1643 1334-417X
Popis:	PBN trapping indicated the presence of at least two types of radicals induced in LDL upon slow oxidation, as observed with EPR spectroscopy. The EPR spectra are very similar to those of the spin probes or spin labels, which are routinely used in the studies of macromolecular systems and supramolecular assemblies. The parameters of the spectral line shapes, treated in two different theoretical models, did not provide conclusive evidence for the phase transition in the LDL particles, known to be present at about 25 °C. It is concluded that both types of trapped radicals, or at least one of them, are associated with the apolipoproteins, with the spin probe sticking into the lipid domain of phospholipids.
Databáze:	OpenAIRE
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