Somatotropin, overview of research studies

Autor: Gaud Dervilly, Marie-Hélène Le Breton, Sandrine Rochereau-Roulet, Ludovic Bailly-Chouriberry, Fanny Kieken, Guido Rychen, Bruno Le Bizec
Přispěvatelé: Ecole Nationale Vétérinaire de Nantes, Nestlé, Fédération Nationale des Courses Françaises, Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL)
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: EuroResidue VI: Conference of Euroresidue on Residues of Veterinary Drugs in Food
EuroResidue VI: Conference of Euroresidue on Residues of Veterinary Drugs in Food, May 2008, Egmond aan Zee, Netherlands
HAL
Residues of Veterinary Drugs in Food: Volume 1. 2008; EuroResidue VI: Conference of Euroresidue on Residues of Veterinary Drugs in Food, Egmond aan Zee, NLD, 2008-05-19-2008-05-21, 120-123
Popis: International audience; Growth hormones (GH, somatotropins ST) exhibit numerous biological effects associated with growth functions. Recombinant GH (rGH) are produced in large quantities and widely used outside Europe to stimulate milk production and as a general growth promoter in meat producing animals. The use of this molecule in animal production is strictly regulated by food safety directives in force. The control of its potential misuse constitutes an analytical challenge which many laboratories have attempted to tackle over the last 15 years. Two strategies can be considered to demonstrate somatotropin treatment to animals, based either on direct or indirect methodologies. Direct methods are focused on the analysis of somatotropin itself, while indirect methods are based on the detection of biological biomarkers with concentrations dependant on ST. Recently, the detection of antibodies produced by the animal after treatment has shown promising results for screening the abuse. In the same time, the challenge of rGH monitoring in biological matrices by means of mass spectrometry has been overcome thanks to the development of efficient purification procedure combined with the use of last MS generation instruments. This presentation overviews the different strategies for the control of GH misuse, focusing on the more recent and promising ones.
Databáze: OpenAIRE
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