A method for nitric oxide radical scavenging properties of sulfur containing compounds

Autor: Vriesman, M.F., Haenen, G.R.M.M., Westerveld, G.J., Paquay, J.B.G., Voss, H.P., Bast, A.
Přispěvatelé: Medicinal chemistry
Jazyk: angličtina
Rok vydání: 1997
Předmět:
Zdroj: Vriesman, M F, Haenen, G R M M, Westerveld, G J, Paquay, J B G, Voss, H P & Bast, A 1997, ' A method for nitric oxide radical scavenging properties of sulfur containing compounds. ', Pharmacy World and Science, vol. 19, pp. 283-286 . https://doi.org/10.1023/A:1008601327920
Pharmacy World and Science, 19, 283-286. Kluwer Academic Publishers
ISSN: 0928-1231
DOI: 10.1023/A:1008601327920
Popis: A new method for the quantification of the nitric oxide (NO) scavenging activity of compounds in aqueous solutions is described using an amperometric NO sensor. After correction for the spontaneous degradation of NO, second-order rate kinetics of the scavenging reaction are observed. The rate constant for haemoglobin found with this method is comparable with that found with an established spectrophotometric method. To demonstrate the capability of the method, several sulfur-containing compounds were tested (GSH, GSSG, S-methyl glutathione, N-acetyl cysteine, lipoic acid and dihydrolipoic acid). Of these compounds, only those that contained a thiol group displayed a considerable NO scavenging activity.
Databáze: OpenAIRE
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