| Autor: |
Mandija, Stefano, Petrov, Petar I., Neggers, Bas, Luijten, Peter R., van den Berg, CAT |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
NMR in Biomedicine, 29(11), 1590. John Wiley and Sons Ltd |
| ISSN: |
0952-3480 |
| Popis: |
Transcranial magnetic stimulation (TMS) is an emerging technique that allows non-invasive neurostimulation. However, the correct validation of electromagnetic models of typical TMS coils and the correct assessment of the incident TMS field (BTMS) produced by standard TMS stimulators are still lacking. Such a validation can be performed by mapping BTMS produced by a realistic TMS setup. In this study, we show that MRI can provide precise quantification of the magnetic field produced by a realistic TMS coil and a clinically used TMS stimulator in the region in which neurostimulation occurs. Measurements of the phase accumulation created by TMS pulses applied during a tailored MR sequence were performed in a phantom. Dedicated hardware was developed to synchronize a typical, clinically used, TMS setup with a 3-T MR scanner. For comparison purposes, electromagnetic simulations of BTMS were performed. MR-based measurements allow the mapping and quantification of BTMS starting 2.5 cm from the TMS coil. For closer regions, the intra-voxel dephasing induced by BTMS prohibits TMS field measurements. For 1% TMS output, the maximum measured value was ~0.1 mT. Simulations reflect quantitatively the experimental data. These measurements can be used to validate electromagnetic models of TMS coils, to guide TMS coil positioning, and for dosimetry and quality assessment of concurrent TMS-MRI studies without the need for crude methods, such as motor threshold, for stimulation dose determination. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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