On-chip detection, sizing and proteomics of extracellular vesicles
| Autor: | Sameh Obeid, Geraldine Lucchi, Thierry Burnouf, Wilfrid Boireau, Céline Caille |
|---|---|
| Přispěvatelé: | Institut National de la Recherche Agronomique (INRA), Taipei Medical University, Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Femto-st, MN2S |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph]
[SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph] [SPI.NANO] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics [SPI.MAT] Engineering Sciences [physics]/Materials [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics [SPI.MAT]Engineering Sciences [physics]/Materials |
| Zdroj: | International Society for Extracellular Vesicles International Society for Extracellular Vesicles, May 2018, Barcelone, Spain HAL |
| Popis: | International audience; Microparticles are small extracellular vesicles (EVs) (from ~100 to 1000 nm) produced by different cell types, through the budding of the plasma membrane, while exosomes (from ~30 to 120 nm) originate from the endolysosomal pathway before fusing with the plasma membrane to be released. Increased platelet-derived microparticles (PMPs) formation has been reported to contribute to the inflammatory role of blood components used for transfusion. When PMPs formation results from thrombin activation, they are able to aggregate monocyte cells in vitro. Nevertheless, the reason(s) for this EVs functionality/effect on target cells still need to be clarified, due to their high variety in size, protein composition and the potential concomitant presence of exosomes and small MPs in the analyzed samples. |
| Databáze: | OpenAIRE |
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