New data on uranium nephrotoxicity [Données nouvelles sur la néphrotoxicité de l'uranium]
| Autor: | Gueguen, Y., Rouas, C. |
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| Přispěvatelé: | Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Institut de Radioprotection et de Sûreté Nucléaire (IRSN/PRP-HOM/SRBE) |
| Jazyk: | francouzština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Radioprotection Radioprotection, 2012, 47 (3), pp.345-359. ⟨10.1051/radiopro/2012015⟩ |
| ISSN: | 0033-8451 |
| Popis: | National audience; Uranium is an element and also a heavy metal to which humans can be exposed due to its natural presence or human activities. It has mainly a chemical toxicity on the proximal convoluted tubules of the kidney after acute or chronic exposure. At high dose exposure, acute tubular nephritis is observed, as indicated by proteinuria and a decreased glomerular filtration rate. More recently, the use of structural biomarkers such as beta 2-microglobuline or tubular enzymes has been correlated with histopathological injury of the proximal convoluted tubules. During chronic exposure at a low level, the use of some of these sensitive and specific biomarkers would be necessary, particularly when the injury is slight. Recent experimental studies in the laboratory have shown the relevance of such new biomarkers as Kim-1 to detect slight renal injury. Uranium exerts its toxicity on epithelial tubular cells in which it accumulates mainly in the nucleus when it is not precipitated. The mechanisms leading to cell death are not totally elucidated but oxidative stress seems to play an important role. © EDP Sciences, 2012. |
| Databáze: | OpenAIRE |
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