Povezanost protutijela na receptor za M-tip fosfolipazu A2 s kliničkim karakteristikama i ishodom bolesnika s primarnom membranskom nefropatijom u 5-godišnjem praćenju
| Autor: | Laganović, Mario, Horvatić, Ivica, Bubić, Ivan, Ilić, Mario, Maksimović, Bojana, Kozmar, Ana, Vuković Brinar, Ivana, Crnogorac, Matija, Živko, Marijana, Fištrek, Margareta, Jureković, Željka, Galešić Ljubanović, Danica, Ćorić, Marijana, Bulimbašić, Stela, Galešić, Krešimir, Knotek, Mladen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina
Membranous nephropathy Membranska nefropatija protutijela na M-tip receptora za fosfolipazu A2 glomerulonefritis M-type phospholipase A2 receptor Glomerulonephritis Medicine Autoantibodies BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine |
| Zdroj: | Acta clinica Croatica Volume 60. Issue Supplement 1 Acta Clinica Croatica, Vol 60., Iss Supplement 1, Pp 71-77 (2021) |
| ISSN: | 1333-9451 0353-9466 |
| Popis: | Introduction: primary membranous nephropathy (pMN) is glomerulopathy caused in the majority of cases by autoantibodies to Phospholipase-A2 receptors (PLA2R-AB). This study aimed to evaluate the clinical course and outcomes of the patients with pMN regarding PLA2R-AB status. Patients and methods: 32 patients (21 males, 11 females) with renal biopsy-proven pMN were included in the study. PLA2R-AB (ELI SA method) and outcomes (defined according to KDIGO) were evaluated after 21 and 64 months of follow-up in 28 patients. Results: 19 patients had positive PLA2R-AB (>20 RU /ml) (59.3%), with median titer of 97 (21-1418 RU /ml). The rate of remission in low PLA2R-AB titer group (< 200 RU /ml) after 21 months was significantly higher than in high PLA2R-AB group (> 200 RU /ml) (90% vs. 50%, p=0.045), and after 64 months the difference was not significant (80% vs. 50%, p=0.210). The relapse rate after 64 months was higher in the high PLA2R-AB group (87% vs. 63%). Multivariant linear regression found serum creatinine (ß=0.682, p Uvod: primarna membranska nefropatija (pMN) je glomerulopatija, koja je u većini slučajeva uzrokovana autoprotutijelima na receptor za fosfolipazu A2 (PLA2R-PT). Cilj ovog istraživanja bio je analizirati povezanost PLA2R-PT s kliničkim tijekom i ishodima bolesti. Ispitanici i metode: 32 bolesnika (21 muškaraca, 11 žena), s biopsijom bubrega dijagnosticiranim pMN, bilo je uključeno u istraživanje. PLA2R-PT (ELI SA metoda) i ishodi (definirani u skladu s KDIGO) određeni su nakon 21 i 64 mjeseca praćenja u 28 bolesnika. Rezultati: 19 bolesnika imalo je pozitivna PLA2R-PT (>20 RU /ml) (59.3%), s medijanom titra 97 (21-1418 RU /ml). Stopa remisije u skupini s niskim titrom PLA2R-PT (< 200 RU /ml) nakon 21 mjeseca bila je značajno viša u odnosu na skupinu s visokim titrom PLA2R-PT (> 200 RU /ml) (90% vs. 50%, p=0.045), a nakon 64 mjeseca razlika nije bila značajna (80% vs 50%, p=0.210). Stopa relapsa nakon 64 mjeseca bila je viša u skupini s visokim titrom PLA2R-PT (87% vs. 63%). Multivarijatnom linearnom regresijom su kao značajni neovisni prediktori za bubrežnu funkciju na kraju praćenja nađeni serumski kreatinin (ß=0.682, p |
| Databáze: | OpenAIRE |
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