| Autor: |
COVID-19 Genomics Belgium Consortium, Cuypers, Lize, Keyaerts, Els, Hong, Samuel Leandro, Gorissen, Sarah, Menezes, Soraya Maria, Starick, Marick, Van Elslande, Jan, Weemaes, Matthias, Wawina-Bokalanga, Tony, Marti-Carreras, Joan, Vanmechelen, Bert, Van Holm, Bram, Bloemen, Mandy, Dogné, Jean-Michel, Dufrasne, François, Durkin, Keith, Ruelle, Jean, De Mendonca, Ricardo, Wollants, Elke, Vermeersch, Pieter, Boulouffe, Caroline, Djiena, Achille, Broucke, Caroline, Catry, Boudewijn, Lagrou, Katrien, Van Ranst, Marc, Neyts, Johan, Baele, Guy, Maes, Piet, André, Emmanuel, Dellicour, Simon, Van Weyenbergh, Johan |
| Přispěvatelé: |
UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Supporting clinical sciences, Microbiology and Infection Control, Clinical Biology |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Nature aging, Vol. 3, no.6, p. 722-733 (2023) |
| Popis: |
Coronavirus Disease 2019 (COVID-19) vaccination has resulted in excellent protection against fatal disease, including in older adults. However, risk factors for post-vaccination fatal COVID-19 are largely unknown. We comprehensively studied three large nursing home outbreaks (20-35% fatal cases among residents) by combining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) aerosol monitoring, whole-genome phylogenetic analysis and immunovirological profiling of nasal mucosa by digital nCounter transcriptomics. Phylogenetic investigations indicated that each outbreak stemmed from a single introduction event, although with different variants (Delta, Gamma and Mu). SARS-CoV-2 was detected in aerosol samples up to 52 d after the initial infection. Combining demographic, immune and viral parameters, the best predictive models for mortality comprised IFNB1 or age, viral ORF7a and ACE2 receptor transcripts. Comparison with published pre-vaccine fatal COVID-19 transcriptomic and genomic signatures uncovered a unique IRF3 low/IRF7 high immune signature in post-vaccine fatal COVID-19 outbreaks. A multi-layered strategy, including environmental sampling, immunomonitoring and early antiviral therapy, should be considered to prevent post-vaccination COVID-19 mortality in nursing homes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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