| Autor: |
Andersson, J., Kinloch, S., Sonnerborg, A., Jakob Nilsson, Fehniger, Te, Spetz, Al, Behbahani, H., Goh, Le, Mcdade, H., Gazzard, B., Stellbrink, H., Cooper, D., Perrin, L. |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Karolinska Institutet |
| Popis: |
Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte (CTL) responses are detectable shortly after the acute phase of HIV infection, but they cannot control viral replication and prevent development of chronic immune suppression. This article describes a defect in the coexpression of perforin in granzyme A-positive CD8+ T cells in lymphoid tissue from patients with acute HIV infection and a reduction in the perforin-dependent nuclear translocation of granzyme A. Furthermore, intracellular levels of HIV DNA and RNA found in lymphoid tissue were higher (10-100 times) than those found in blood, and blood samples showed more-coordinated cellular perforin/granzyme A expression. This suggests that mechanisms inhibiting CTL-mediated cytotoxicity are operative in lymphoid tissue early in the course of HIV infection |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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