Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association

Autor: Doehner, Wolfram, Ural, Dilek, Haeusler, Karl Georg, Celutkiene, Jelena, Bestetti, Reinaldo, Cavusoglu, Yuksel, Pena-Duque, Marco A., Glavas, Duska, Iacoviello, Massimo, Laufs, Ulrich, Marmol Alvear, Ricardo, Mbakwem, Amam, Piepoli, Massimo F., Rosen, Stuart D., Tsivgoulis, Georgios, Vitale, Cristiana, Yilmaz, M. Birhan, Anker, Stefan D., Filippatos, Gerasimos, Seferovic, Petar, Coats, Andrew J. S., Ruschitzka, Frank
Přispěvatelé: [Doehner, Wolfram -- Haeusler, Karl Georg] Charite, Ctr Stroke Res Berlin CSB, Berlin, Germany -- [Doehner, Wolfram -- Anker, Stefan D.] Charite, Div Cardiol & Metab, Dept Cardiol CVK, Deutsch Zentrum Herz Kreislauf Forsch DZHK, Berlin, Germany -- [Doehner, Wolfram -- Anker, Stefan D.] Charite, Berlin Brandenburg Ctr Regenerat Therapies BCRT, Berlin, Germany -- [Ural, Dilek] Koc Univ, Sch Med, Dept Cardiol, Istanbul, Turkey -- [Haeusler, Karl Georg] Charite, Dept Neurol, Berlin, Germany -- [Celutkiene, Jelena] Vilnius Univ, Ctr Cardiol, Clin Cardiac & Vasc Dis, Vilnius, Lithuania -- [Bestetti, Reinaldo] Univ Ribeirao Preto, Dept Med, Ribeirao Preto, Brazil -- [Cavusoglu, Yuksel] Eskisehir Osmangazi Univ, Cardiol Dept, Eskisehir 9, Turkey -- [Pena-Duque, Marco A.] Natl Inst Cardiol Ignacio Chavez, Mexico City 10, DF, Mexico -- [Glavas, Duska] Univ Hosp Split, Cardiol Dept, Split, Croatia -- [Iacoviello, Massimo] Univ Hosp, Univ Cardiol Unit, Cardiothorac Dept, Bari 12, Italy -- [Laufs, Ulrich] Univ Klinikum Leipzig, Klin & Poliklin Kardiol, Leipzig, Germany -- [Marmol Alvear, Ricardo] Hosp Clin Kennedy, Guayaquil, Ecuador -- [Mbakwem, Amam] Univ Lagos, Coll Med, Lagos 1, Nigeria -- [Piepoli, Massimo F.] Guglielmo da Saliceto Hosp, Heart Failure Unit, Cardiol, Piacenza, Italy -- [Rosen, Stuart D.] Imperial Coll, Ealing Hosp, London, England -- [Rosen, Stuart D.] Imperial Coll, Royal Brampton Hosp, London, England -- [Rosen, Stuart D.] Imperial Coll, NHLI, London, England -- [Tsivgoulis, Georgios] Univ Athens, Athens, Greece -- [Vitale, Cristiana -- Coats, Andrew J. S.] IRCCS San Raffaele Pisana, Dept Med Sci, Rome, Italy -- [Yilmaz, M. Birhan] Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- [Anker, Stefan D.] Univ Gottingen, Dept Cardiol & Pneumol, Med Ctr, Gottingen, Germany -- [Filippatos, Gerasimos] Univ Athens, Attikon Univ Hosp, Athens, Greece -- [Seferovic, Petar] Univ Belgrade, Fac Med, Clin Ctr Serbia, Belgrade, Serbia -- [Ruschitzka, Frank] Univ Hosp Zurich, Univ Heart Ctr, Dept Cardiol, Zurich, Switzerland, piepoli, massimo francesco -- 0000-0003-1124-234X, YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628, Celutkiene, Jelena -- 0000-0003-3562-9274, URAL, DILEK -- 0000-0003-0224-1433
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Popis: WOS: 000429044500004
PubMed ID: 29280256
Heart failure (HF) is a complex clinical syndrome with multiple interactions between the failing myocardium and cerebral (dys-)functions. Bi-directional feedback interactions between the heart and the brain are inherent in the pathophysiology of HF: (i) the impaired cardiac function affects cerebral structure and functional capacity, and (ii) neuronal signals impact on the cardiovascular continuum. These interactions contribute to the symptomatic presentation of HF patients and affect many co-morbidities of HF. Moreover, neuro-cardiac feedback signals significantly promote aggravation and further progression of HF and are causal in the poor prognosis of HE The diversity and complexity of heart and brain interactions make it difficult to develop a comprehensive overview. In this paper a systematic approach is proposed to develop a comprehensive atlas of related conditions, signals and disease mechanisms of the interactions between the heart and the brain in HF. The proposed taxonomy is based on pathophysiological principles. Impaired perfusion of the brain may represent one major category, with acute (cardio-embolic) or chronic (haemodynamic failure) low perfusion being sub-categories with mostly different consequences (i.e. ischaemic stroke or cognitive impairment, respectively). Further categories include impairment of higher cortical function (mood, cognition), of brain stem function (sympathetic over-activation, neuro-cardiac reflexes). Treatment-related interactions could be categorized as medical, interventional and device-related interactions. Also interactions due to specific diseases are categorized. A methodical approach to categorize the interdependency of heart and brain may help to integrate individual research areas into an overall picture.
Heart Failure Association of the European Society of Cardiology
The workshop on heart and brain interaction in patients with heart failure was funded by the Heart Failure Association of the European Society of Cardiology.
Databáze: OpenAIRE
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