A three base pair gene variation within the distal 5'-flanking region of the interleukin-10 (IL-10) gene is related to the in vitro IL-10 production capacity of lipopolysaccharide-stimulated peripheral blood mononuclear cells

Autor:	Rieth, H., Mormann, M., Luty, J.F., Assohou-Luty, C.A., Roupelieva, M., Kremsner, P.G., Kube, D.
Rok vydání:	2004
Předmět:	Microbial pathogenesis and host defense [UMCN 4.1]
Zdroj:	European Cytokine Network, 15, 2, pp. 153-8 Scopus-Elsevier European Cytokine Network, 15, 153-8
ISSN:	1148-5493
Popis:	Item does not contain fulltext Interleukin-10 (IL-10) is an important multifunctional immunmodulator. There is evidence that IL-10 secretion is associated with certain genetic elements of the proximal IL-10 gene 5'-flanking region. The allelic and genotypic comparison of IL-10 expression by lipopolysaccharide (LPS)- stimulated leukocytes (PBMC) with a recently discovered distal "indel" DNA-sequence variation at - 7400 bp revealed significant inter-individual differences in the IL-10 in vitro production capacity. Homozygotes lacking the three base pairs "GGA" (- 7400del) at this gene locus are characterised by high expression of IL-10 with a median of 1690pg/ml (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ec31c9214ddb9972be2f75b21e906533 https://hdl.handle.net/2066/57578 Zobrazit plný text záznamu