Influence of chronic smoking on the dose due to radon exposure
| Autor: | Honorio da Silva, Edilaine, Davesne, Estelle, Bonchuk, Y., Ratia, G., Madas, B., Berkovskyy, V., Broggio, David |
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| Přispěvatelé: | Laboratoire d'évaluation de la dose interne (IRSN/PSE-SANTE/SDOS/LEDI), Service de dosimétrie (IRSN/PSE-SANTE/SDOS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Institut National des Sciences et Techniques Nucléaires (INSTN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Ukrainian Radiation Protection Institute, Centre for Energy Research [Budapest] (MTAE), Hungarian Academy of Sciences (MTA), European Project: 900009,RadoNorm |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | ERPW2022-6th European Radiation Protection Week ERPW2022-6th European Radiation Protection Week, Oct 2022, Estoril (Portugal), Portugal |
| Popis: | International audience; IntroductionLung cancer is the second most common type of cancer worldwide, with two major causes being smoking and radon exposure. But how chronic smoking affects radon doses to the lungs is not clear. In this study, we identified smoking related parameters that could influence the dose received by the lungs from radon.MethodsChanges in the lungs and respiratory functions caused by smoking found in the literature were used to adjust the Human Respiratory Tract Model and calculations were performed to assess the influence of smoking on the radon doses.Also based in the literature a new dose calculation tool for quantitative assessment of the impact of smoking and other factors, such as age, sex, nasal or mouth breathing habits is under preparation. To ensure the quality of calculations, the developed code is applied for the quality assurance programme of the ICRP Task Group on Internal Dose Coefficients and in the preparation of ICRP publications and electronic datasets. Additionally, PHITS was used for validation of the energy transport calculations. These tools will incorporate functionalities for the analysis of the sensitivity of estimates of lung tissue absorbed doses to changes in the lung deposition pattern, source-target geometry and biokinetics associated with smoking.ResultsSmoking was found to change the thickness of epithelial layers and length of cilia in the respiratory tract and influence respiratory parameters. Clearance of inhaled aerosol also differs in smokers and non-smokers, indicating that smoking could influence absorption into blood and muco-ciliary transport. A pilot version of the tool for calculating the alpha particles energy deposition in the tissues of the human respiratory tract has been developed.ConclusionsData available from the literature suggests that smoking could lead to changes relevant to the calculation of radiation doses in the respiratory tract, potentially impacting the dose received by smokers due to radon. |
| Databáze: | OpenAIRE |
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