New analysis of the mechanisms controlling the bronchial mucus balance
| Autor: | Cyril Karamaoun, Benjamin Sobac, Benjamin Mauroy, Alain van Muylem, Benoit Haut |
|---|---|
| Přispěvatelé: | COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), LJAD, Laboratoire Jean Alexandre Dieudonné (JAD), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Transfers, Interfaces and Processes (TIPs), Université libre de Bruxelles (ULB), VADER Center, Université de Nice Côte d'Azur, Centre National de la Recherche Scientifique (CNRS), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
fluids and secretions
mucus [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] cilia respiratory physiology [PHYS.MECA.THER]Physics [physics]/Mechanics [physics]/Thermics [physics.class-ph] [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] respiratory system epithelium [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract respiratory tract diseases evaporation |
| Zdroj: | Proceedings of the 27th CANCAM, to appear in volume 3 of Progress in Canadian Mechanics. 27th Canadian Congress of Applied Mechanics 27th Canadian Congress of Applied Mechanics, May 2019, Sherbrooke, Canada HAL |
| Popis: | International audience; Lining the bronchi in the lung, the mucus constitutes a protective layer from harmful pathogens and particles. Its displacement due to the coordinated beating of the bronchial epithelium cilia contributes to its clearance from the lung. As this mucociliary clearance is impaired in numerous pathologies, a comprehensive understanding of this process is critical. A simple mass balance over the mucus layer in an airway suggests that the cilia beating, on its own, is not sufficient enough for controlling the bronchial mucus balance in the entire lung. In this article, we show through a mathematical modeling approach that the evaporation of the water contained in the mucus layer could act as a control mechanism of the mucus balance. Furthermore, we suggest that other control mechanisms act in parallel to evaporation to maintain the mucus balance. Our model and results could be useful in the study and management of several mucus-related airway diseases , such as cystic fibrosis or exercise-induced asthma. |
| Databáze: | OpenAIRE |
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