Synergistic effect of thrombus aspiration and abciximab in primary percutaneous coronary intervention

Autor: Pyxaras, Sa, Mangiacapra, F, Verhamme, K, Di Serafino, L, De Vroey, F, Toth, G, Perkan, A, Salvi, A, Bartunek, J, De Bruyne, B, Wijns, W, Sinagra, Gianfranco, Barbato, E.
Přispěvatelé: Pyxaras, Sa, Mangiacapra, F, Verhamme, K, Di Serafino, L, De Vroey, F, Toth, G, Perkan, A, Salvi, A, Bartunek, J, De Bruyne, B, Wijns, W, Sinagra, G, Barbato, Emanuele, Sinagra, Gianfranco, Barbato, E.
Rok vydání: 2013
Předmět:
Popis: BACKGROUND: Previous studies failed to assess the individual prognostic role of thrombus aspiration (TA) or abciximab in primary percutaneous coronary intervention (pPCI), due their prevalent combined use. METHODS AND RESULTS: A total of 644 consecutive ST-segment elevation myocardial infarction patients treated with pPCI were included in this retrospective registry from January 2006 to December 2008. Patients were divided in: (a) Group 1, with conventional pPCI; (b) Group 2, with pPCI and abciximab; (c) Group 3, with pPCI and TA; (d) Group 4, with pPCI and abciximab plus TA. Primary end point was the composite of major adverse cardiovascular events (MACEs, defined as overall mortality, myocardial infarction, target vessel revascularization, and major bleedings) at 1 year. Baseline clinical and angiographic characteristics were not different among the groups, with the exception of a younger age in group 4. The two groups of patients treated with TA (group 3 and 4) received more frequently direct stenting (P
Databáze: OpenAIRE