Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities
| Autor: | Kazakova, Oxana, brunel, jean michel, Khusnutdinova, Elmira, Negrel, Sophie, Giniyatullina, Gulnara, Lopatina, Tatyana, Petrova, Anastasiya |
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| Přispěvatelé: | Russian Academy of Sciences (Ufa), Membranes et cibles thérapeutiques (MCT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées (IRBA), Russian Foundation for Basic Research (project no. 18-33-00364 mol_ato Tatyana V. Lopatina). |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Molbank Molbank, MDPI, 2019, 2019 (3), pp.M1078. ⟨10.3390/M1078⟩ |
| ISSN: | 1422-8599 |
| DOI: | 10.3390/M1078⟩ |
| Popis: | International audience; Some new β-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino β-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC 50 values. |
| Databáze: | OpenAIRE |
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