Fabrication of patient specific composite orbital floor implants by stereolithography

Autor: Geven, Mike Alexander, Varjas, V., Kamer, L., Wang, X., Peng, J., Eglin, D., Grijpma, Dirk W.
Přispěvatelé: Nanotechnology and Biophysics in Medicine (NANOBIOMED), Faculty of Science and Technology, Biomaterials Science and Technology
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Polymers for Advanced Technologies, 26(12), 1433-1438. Wiley
Polymers for advanced technologies, 26(12), 1433-1438. Wiley
ISSN: 1042-7147
Popis: Fractures of the orbital floor are common in traffic accidents and assaults, and inadequate treatment can result in serious complications. Accurate anatomical reconstruction of the orbit using implants is the preferred treatment. Implants require degradability, adequate mechanical properties to support the orbital contents, and osteoinductivity or osteoconductivity so that the implant is replaced by de novo bone over time. Here, we report on a semi-automatic process for the generation of virtual models of patient-specific implants for orbital floor reconstruction. These models were generated using clinical computed tomography images of five clinical cases of orbital fracture. To fabricate accurately shaped implants based on the models, we utilized stereolithography, a high-resolution additive manufacturing technique. We prepared resins from bioresorbable, photo-curable functionalized poly(trimethylene carbonate) oligomers and osteoinductive nano-hydroxyapatite to manufacture composite implants. Incorporation of 40 wt.% nano-hydroxyapatite into photo-crosslinked poly(trimethylene carbonate) leads to an increase of the E modulus, ultimate strength and toughness from 2.8 to 60 MPa, 2.4 to 7.1 N/mm2 and 330 to 1671 N/mm2, respectively. Additionally, water uptake increased from 0.8% to 7.3%, and water contact angle decreased from 80 degrees to 68 degrees. Patient-specific, homogeneous, and mechanically stable implants can readily be prepared using these composite resins. Copyright (C) 2015 John Wiley & Sons, Ltd.
Databáze: OpenAIRE
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