The First CNS-Active Carbarone: A Novel P2X7 Receptor Antagonist with Antidepressant Activity
| Autor: | Wilkinson, Shane M, Rendina, Louis M, Kassiou, Michael, Gunosewoyo, Hendra, Barron, Melissa L, Boucher, Aurelie, McDonnell, Michelle, Turner, Peter, Morrison, Daniel E, Bennett, Maxwell R, McGregor, Iain S |
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| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | ACS Chem. Neurosci. 5(5) 335–339 (2014) ZENODO Europe PubMed Central |
| Popis: | Relative to other polycyclic frameworks (1–3), a carborane cage (4and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity. |
| Databáze: | OpenAIRE |
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