Effect of statins on melanoma of the skin
| Autor: | Koomen, E. R., Joosse, A., Herings, R. M.C., Casparie, M. K., Bergman, W., Nijsten, T., Guchelaar, H. J. |
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| Přispěvatelé: | Epidemiology and Data Science |
| Jazyk: | Dutch; Flemish |
| Rok vydání: | 2007 |
| Zdroj: | Koomen, E R, Joosse, A, Herings, R M C, Casparie, M K, Bergman, W, Nijsten, T & Guchelaar, H J 2007, ' Effecten van statines op huidmelanomen ', Pharmaceutisch Weekblad, vol. 142, no. 42, pp. 133-137 . Pharmaceutisch Weekblad, 142(42), 133-137. Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP) |
| ISSN: | 0031-6911 |
| Popis: | Objective: To investigate the effect of statins on the incidence and tumour thickness of cutaneous melanoma (CM). Design: In a case control study we examined the association between statins, development of CM and Breslow thickness. Data from PHARMO, containing drug dispensing records of over 2 million Dutch residents, were linked to PALGA, containing abstracts of pathological examinations of over 9 million Dutch patients. Cases were eligible if they had a primary CM diagnosis between 1 January 1991 and 14 December 2004, were 18 years or older and had 3 years of PHARMO follow-up before diagnosis. For every included case, controls were sampled matched for gender, age and geographic region. Methods: A multivariate logistic regression model was used to investigate CM incidence. To study Breslow thickness, a multiple linear regression model was used. We adjusted for age, gender, year of diagnosis, number of medical diagnoses and the use of NSAIDs and estrogens. Results: 1318 eligible cases and 6786 eligible controls were identified. Statin use (≥ 0.5 year) was not associated with reduced risk of CM (adjusted OR 0.983, CI95 0.778-1.242). However, statin use was associated with reduced Breslow thickness (-19.2 %, CI95 -33.2- -2.3, p = 0.028). These findings were confirmed in men but not in women. In men, every increase of 0.66 DDD (Daily Defined Dose) in average day dose significantly reduced Breslow thickness (-11.0, CI95 -19.7- -1.2, p = 0.029). Conclusion: Our study suggests a protective effect of statins on the progression of melanoma. A validation of our findings, preferably in a prospective randomized study, is warranted. |
| Databáze: | OpenAIRE |
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