Anti-Mycobacterium tuberculosis and Cytotoxicity Activities of Ruthenium(II)/ Bipyridine/Diphosphine/Pyrimidine-2-thiolate Complexes: The Role of the Non- Coordinated N-Atom
| Autor: | Lima, Benedicto A. V., Corrêa, Rodrigo S., Graminha, Angelica E., Kuznetsov, Aleksey, Ellena, Javier, Pavan, Fernando R., Leite, Clarice Q. F., Batista, Alzir A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
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| Zdroj: | Journal of the Brazilian Chemical Society v.27 n.1 2016 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ Journal of the Brazilian Chemical Society, Volume: 27, Issue: 1, Pages: 30-40, Published: JAN 2016 |
| Popis: | The [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1'-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacteriumtuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA. |
| Databáze: | OpenAIRE |
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