Chemical synthesis of fragments of streptococcal cell wall polysaccharides

Autor:	Wang, Z.
Přispěvatelé:	Codée, J.D.C., Marel, G.A. van der, Overkleeft, H.S., Brouwer, J., Artola Perez de Azanza, M.E., Huang, X., Wennekes, T., Leiden University
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Group A carbohydrate Zwitterionic polysaccharides Synthetic oligosaccharides Streptococcus Group B-specific antigen Synthetic carbohydrate-based vaccines
Zdroj:	None
Popis:	This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular polysaccharide of Streptococcus pneumonia (Sp1). All the synthesized fragments were equipped with a spacer at the reducing end for further conjugation with proteins or active small molecules to explore the mechanisms of carbohydrate-based vaccines in immune responses and to develop novel vaccines. To investigate the structure-activity relationship, several fragments of each polysaccharide were assembled varying in length.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e59174bbaddf8e02f6282a50ea950dac https://hdl.handle.net/1887/137445 Zobrazit plný text záznamu