| Autor: |
Leyssens, Lisa, Ryelandt, Sophie, Favache, Audrey, Kerckhofs, Greet |
| Přispěvatelé: |
UCL - SST/IMMC/MEED - Mechatronic, Electrical Energy, and Dynamics Systems, UCL - SST/IMMC/IMAP - Materials and process engineering |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
The bone-tendon interface is a highly specialized tissue connecting tendon to bone. The function of the bone-tendon interface is to mediate load between two very dissimilar tissues: the bone which is hard and stiff, and the tendon which is a soft tissue. Injuries occurring at this interface commonly result in pain, disability and significant medical costs. These injuries are commonly caused by sports activities or can be seen in elderly people, making them less mobile because of the inability to move without pain. Moreover, the chances of failure of surgical reattachment are still very high. Therefore, the bone-tendon interface is an important research topic. Nanoindentation is a powerful method for mechanical characterization of biological tissues. It allows assessing the tissues at high resolution and in different directions, and it can be used to characterize complicated local mechanical properties of heterogeneous materials. However, measurements remain challenging specifically for the bone-tendon interface because of the presence of highly dissimilar tissues. Moreover, sample preparation, which is a crucial step, is non-trivial for small biological tissues with highly heterogeneous properties. Therefore, the goal of this study was to optimize the sample preparation for nanoindentation of the bone-tendon interface at the site of the murine Achilles tendon-to-heel bone. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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