Outcome of a second-line protease inhibitor - Containing regimen in patients failing or intolerant of a first highly active antiretroviral therapy
| Autor: | Bini, T., Testa, L., Chiesa, E., Fulvio Adorni, Abeli, C., Castelnuovo, B., Melzi, S., Sollima, S., Bongiovanni, M., D Arminio Monforte, A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: | |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999) 24 (2000): 115–122. info:cnr-pdr/source/autori:Bini T.; Testa L.; Chiesa E.; Adorni F.; Abeli C.; Castelnuovo B.; Melzi S.; Sollima S.; Bongiovanni M.; D'Arminio Monforte A./titolo:Outcome of a second-line protease inhibitor-Containing regimen in patients failing or intolerant of a first highly active antiretroviral therapy/doi:/rivista:Journal of acquired immune deficiency syndromes (1999)/anno:2000/pagina_da:115/pagina_a:122/intervallo_pagine:115–122/volume:24 Scopus-Elsevier |
| Popis: | The outcome of second-line protease inhibitor (PI)-containing highly active antiretroviral therapy (HAART) was investigated in 263 patients who were failed by (n 148) or intolerant of (n 115) a first HAART regimen. The endpoints were virologic failure (decline in HIV RNA 34 years versus 34 years: 95% CI, 0.42-0.88), a saquinavir-containing first HAART (HR 0.57 versus indinavir: 95% CI, 0.34-0.93) and change due to intolerance/toxicity (HR 0.58 versus failure: 95% CI, 0.35-0.98). The independent variables predictive of discontinuation due to intolerance/toxicity were the reason for switching (HR 1.79 intolerance versus failure: 95% CI, 1.02-3.16) and the first protease inhibitor (PI) regimen (HR 0.42 ritonavir versus indinavir: 95% CI, 0.22-0.80). Given that patients who are failed by a first regimen are at high risk of having rescue therapy fail as well, second-line regimens including therapies directed by testing of drug resistance patterns of clinical viral isolates are warranted. Patients experiencing toxicity due to a first PI-containing regimen are at risk of toxicity to other PIs and should be addressed to PI-sparing HAART. |
| Databáze: | OpenAIRE |
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