Pharmacokinetic/Pharmacodynamic Assessment of irrelevant drug concentrations in horse plasma or urine for a selection of drugs
| Autor: | Toutain, Pierre-Louis, Lassourd, V. |
|---|---|
| Přispěvatelé: | Physiopathologie et Toxicologie Expérimentales (UPTE), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Proceedings of the 14th International Conference of Racing Analysts and Veterinarians: Orlando, Florida, USA Proceedings of the 14th International Conference of Racing Analysts and Veterinarians: Orlando, Florida, USA, 2002, Orlando, United States Proceedings of the 14th International Conference of Racing Analyts and Veterinarians. 2002; Proceedings of the 14th International Conference of Racing Analysts and Veterinarians: Orlando, Florida, USA, Orlando, USA, 2002-, 19-28 |
| Popis: | International audience; The lower limits of detection of the analytical techniques currently used for drug testing in horses result in the dilemma of whether or not to report trace levels of drugs legitimately used for therapeutic medication. A non-experimental pharmacokinetic/pharmacodynamic approach for the determination of irrelevant drug plasma concentrations (IPC) and irrelevant urine concentrations (IUC) has been put forward by Toutain and Lassourd (2002). The published plasma clearance is used to transform an effective dose into an effective concentration (EPC). EPC is then transformed into an IPC by applying a safety factor (SF). This method is based on several assumptions ( eg drug effects reversibly driven by plasma concentration, linearity of drug disposition). To explore the feasibility and attractiveness of this approach, this article reports EPC, IPC and IUC for a selection of drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|