CELL-WALL FRACTIONS FROM PARACOCCIDIOIDES-BRASILIENSIS INDUCE HYPERGAMMAGLOBULINEMIA
| Autor: | Deoliveira, Sl, Dasilva, Mf, Soares, Amvd, Celio Silva |
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| Přispěvatelé: | Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: | |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP ResearcherID |
| Popis: | Made available in DSpace on 2020-12-10T20:12:09Z (GMT). No. of bitstreams: 0 Previous issue date: 1993-01-01 The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis. UNIV SAO PAULO, SCH MED RIBEIRAO PRETO, DEPT PARASITOL MICROBIOL & IMMUNOL, BR-14049 RIBEIRAO PRETO, SP, BRAZIL UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, DEPT MICROBIOL & IMMUNOL, BOTUCATU, SP, BRAZIL UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO, DEPT MICROBIOL & IMMUNOL, BOTUCATU, SP, BRAZIL |
| Databáze: | OpenAIRE |
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