Therapeutic vaccination (p24-VLP) of patients with advanced HIV-1 infection in the pre-HAART era does not alter CD4 cell decline

Autor: Smith, D., Gow, I., Colebunders, R., Weller, I., Tchamouroff, S., Weber, J., Boag, F., Hales, G., Adams, S., Patou, G., Cooper, D. A.
Přispěvatelé: 006 Study Group
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Zdroj: HIV medicine
ISSN: 1464-2662
Popis: The definitive version is available at www3.interscience.wiley.com
In a randomized placebo controlled trial 304 HIV infected patients with CD4 cell counts below 350 cells/microL received therapeutic vaccination with: alum placebo (Group I, n = 102), p24-VLP 500 microg (Group II, n = 101) or p24-VLP 1000 microg (Group III, n = 101) p24-VLP monthly for six months. Over one year the average change in CD4 cell count did not differ significantly between groups (-32, -40 and -52 cells per microL respectively). There was also no difference between groups in progression to CDC category B or C events, or in adverse events. Therapeutic vaccination with p24-VLP does not affect CD4 cell decline in patients with advanced HIV infection.
Databáze: OpenAIRE
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