Progesterone-induced spike-wave discharges are inhibited by finasteride
| Autor: | Budziszewska, B., Tetich, M., Luijtelaar, E.L.J.M. van, Lason, W., Kuznetsova, G.D., Coenen, A.M.L., Chepurnov, S.A. |
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| Přispěvatelé: | Luijtelaar, E.L.J.M. van, Kuznetsova, G.D., Coenen, A.M.L., Chepurnov, S.A. |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L. (ed.), The WAG/Rij model of absence epilepsy: the Nijmegen-Russian Federation papers, pp. 149-161 Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L. (ed.), The WAG/Rij model of absence epilepsy: the Nijmegen-Russian Federation papers, 149-161. Nijmegen : NICI STARTPAGE=149;ENDPAGE=161;TITLE=Luijtelaar, E.L.J.M. van; Kuznetsova, G.D.; Coenen, A.M.L. (ed.), The WAG/Rij model of absence epilepsy: the Nijmegen-Russian Federation papers |
| Popis: | Item does not contain fulltext Previously, it was found that progesterone aggravates spike-wave discharges (SWD) in WAG/Rij rats in a non-genomic way. In order to elucidate whether the regulatory effect of progesterone depends on its conversion to allopregnanolone, the effect of finasteride, a 5?-reductase inhibitor, on progesterone-induced increase in SWD was studied in the same model for absence epilepsy. Progesterone (10 and 20 mg/kg, i.p.) dose-dependently increased the number of SWD (by 54 and 97 %, respectively) during the first hour post-injection. Pretreatment of rats with finasteride (50 mg/kg, s.c.) blocked the progesterone-induced enhancement of SWD. Finasteride alone had no effect on the number of SWD, up to 24 hours following its administration. It is concluded that finasteride blocked the progesterone-induced increase in SWD, which indicates that this action of progesterone is mediated by its neuroactive metabolite allopregnanolone. |
| Databáze: | OpenAIRE |
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