A Pilot Study of Effects of Ecolostrum on Salivary IgA

Autor: Ivana MEDVEDEC MIKIĆ, Blaženka LADIKA DAVIDOVIĆ, Jurica Matijević, Goranka PRPIĆ MEHIČIĆ, Silvana JUKIĆ KRMEK
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Acta stomatologica Croatica : International journal of oral sciences and dental medicine
Volume 46
Issue 2
ISSN: 0001-7019
1846-0410
Popis: Svrha rada: Svrha ove studije bila je procijeniti utjecaj oralne primjene Ekolostruma (goveđeg kolostruma) na koncentraciju salivarnog IgA (sIgA). Materijali i metode: Dvadesetero zdravih ispitanika u dobi između 23 i 54 godine nasumce je podijeljeno na ispitnu i kontrolnu skupinu (n = 10). Svatko u ispitnoj skupini dobio je 60 kapsula Ekolostruma. Na početku istraživanja od svih je sudionika bila prikupljena nestimulirana slina. To isto učinjeno je nakon 30 dana, na kraju pokusa. Koncentracija sIgA iz sline određivala se testom ELISA (enzim-linked immunosorbent assay). Usporedbe rezultata unutar skupine obavljene su studentovim t-testom, a usporedbe rezultata između dviju skupina primjenom ANOVE (p=0,05). Rezultati: Sudionici ispitivanja koji su uzimali Ekolostrum imali su statistički značajno (p = 0,026) niže koncentracije sIgA nakon tretmana negoli prije. Kontrolna skupina nije pokazala statistički značajnu razliku u koncentraciji sIgA na početku i na kraju istraživanja. Na kraju istraživanja nije bilo statistički značajne razlike (p = 0,047) srednjih koncentracija sIgA između ispitne i kontrolne skupine (464 ± 59.89μg/mL i 620,16 ± 42.26μg/mL). Zaključak: Rezultati ovog istraživanja pokazuju da je nakon jednomjesečne oralne primjene Ekolostruma koncentracija sIgA bila statistički značajno niža nego prije tretmana. Potrebna su daljnja, opsežnija i detaljnija istraživanja kako bismo dobili pouzdanije rezultate.
Objective: The aim of the present pilot- study was to evaluate the influence of oral intake of Ekolostrum (bovine colostrum) on concentration of salivary IgA( sIgA) in saliva. Materials and Methods: Twenty healthy participants between 23 and 54 years of age were randomly selected for the test and control group (n= 10). The test group took 60 capsules of Ecolostrum. The entire amount of the unstimulated saliva was collected before treatment from all participants. The procedure was repeated after 30 days at the end of the experiment. The concentration of sIgA in saliva was determined using ELISA (enzyme- linked immunosorbent assay). Intra- group comparisons were performed by paired sample T-test and inter- group differences were compared by ANOVA (p=0.05) Results: Participants who were taking Ecolostrum had statistically significant (p=0.026) lower concentrations of sIgA after the treatment than before. The control group showed no statistically significant difference. There were statistically significant differences ( p=0.047) of mean concentrations of sIgA between the test group and control group at the end of the experiment(464 ±59.89μg/mL and 620.16± 42.26μg/mL). Conclusions: The results of this pilot- study show that after one month of orally administrated Ekolostrum, the amount of sIgA was lower than before treatment. Some more extensive and detailed studies are needed to obtain more reliable results.
Databáze: OpenAIRE
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