Atrophic scar formation in acne patients involves long-acting immune responses with plasma cells and alteration of sebaceous glands

Autor: Carlavan, I, Bertino, B, Rivier, M, Martel, P, Bourdes, V, Motte, M, Déret, S, Reiniche, P, Menigot, C, Khammari, Amir, Dréno, Brigitte, Fogel, P, Voegel, Johannes
Přispěvatelé: Galderma Recherche et Développement [Biot, France] ( Galderma R&D ), Clinical and translational research in skin cancer ( CRCINA - Département INCIT - Equipe 2 ), Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers ( CRCINA ), Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ) -Université d'Angers ( UA ) -Université de Nantes ( UN ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche en Santé de l'Université de Nantes ( IRS-UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ), Galderma Recherche et Développement [Biot, France] (Galderma R&D), Clinical and Translational Research in Skin Cancer (CRCINA-ÉQUIPE 2), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: British Journal of Dermatology
British Journal of Dermatology, Wiley, 2018, Epub ahead of print. 〈10.1111/bjd.16680〉
British Journal of Dermatology, Wiley, 2018, Epub ahead of print. ⟨10.1111/bjd.16680⟩
ISSN: 0007-0963
1365-2133
DOI: 10.1111/bjd.16680〉
Popis: International audience; BACKGROUND:Possible outcomes of acne lesions are atrophic scars which may cause serious psychological distress. Current treatments of post-acne scarring often require invasive procedures. Pathophysiological studies on acne scarring investigated only the first week of papule life.OBJECTIVES:Study the pathophysiology of atrophic scar formation to identify molecular and cellular pathways that can lead to new therapies for the prevention of acne scarring.METHODS:Large-scale gene expression profiling and immunohistochemistry analysis were performed on uninvolved skin and papules in both, scar-prone (SP) and non-scar-prone (NSP) acne patients, at different time points.RESULTS:Gene expression and immunohistochemistry analyses showed a very similar immune response in 48 hours-old papules in SP and NSP populations, characterized by elevated numbers of T cells, neutrophils and macrophages. However, only in SP patients the immune response persisted in 3 week-old papules, and was characterized by an important infiltrate of B cells. Transient down-modulation of sebaceous gland markers related to lipid metabolism was observed in 48 hours-old papules in NSP patients, followed by normalization after 3 weeks. In contrast, in SP patients a drastic reduction of these markers persisted in 3 week-old papules, suggesting an irreversible destruction of sebaceous gland structures after inflammatory remodelling in SP acne patients.CONCLUSIONS:Long lived acne papules are characterized by a B cell infiltrate. A relationship exists between the duration and severity of inflammation and the alteration of sebaceous gland structures, leading to atrophic scar formation in acne. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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