Physical, chemical and biological modelling of the radiosensitizing effect of high-Z nanoparticles

Autor: Poignant, Floriane, Gervais, Benoit, Ipatov, Andrei, Monini, Caterina, Testa, Etienne, Beuve, Michael
Přispěvatelé: Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Saint Petersburg State Technical University, Saint Petersburg State Polytechnical University (SPSPU), ANR-11-LABX-0063,PRIMES,Physique, Radiobiologie, Imagerie Médicale et Simulation(2011), Rayet, Béatrice, Physique, Radiobiologie, Imagerie Médicale et Simulation - - PRIMES2011 - ANR-11-LABX-0063 - LABX - VALID, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: ICRR 2019
ICRR 2019, Aug 2019, Manchester, United Kingdom
Popis: International audience; Background: In radiotherapy, the use of radiosensitizers aims at amplifying the destructive effects of the dose in the tumor. High-Z nanoparticles have shown promising radiosensitizing properties that may originate from early physical and chemical mechanisms. A local amplification of the energy deposition inside nanotargets such as DNA, in addition to a boost of free radicals could be responsible for an increase of cell death. While it has been studied for over a decade, the understanding of such effects remains under investigation.Goal: As experimental results appear sometimes contradictory, modelling may help to better understand and quantify these early mechanisms and their impacts on cell survival.Methods: We developed Monte Carlo simulations (MCS) which track secondary electrons down to low energy both in water (meV) and gold (eV). These MCS were used to calculate the two following quantities, for an irradiated volume of water containing nanoparticles:(1) the statistical distribution of energy deposition in nanotargets, and the impact of nanoparticles on this distribution, with regard to the distance of the nanotarget to the nanoparticle surface.(2) the boost of free-radical production induced by nanoparticles, both at macro- and nanoscale.We emphasize that the time for such calculations would be prohibitive (>500 centuries on a PC) without several numerical optimizations. These two results were used in the biophysical model NanOx, originally developed to predict biological dose in hadrontherapy, to quantify the effect of nanoparticles in terms of cell death.Results: The effect of gold nanoparticles on these 3 quantities will be presented for irradiation with 20-90 keV photons, various nanoparticle sizes and concentrations.Conclusion: Nanoparticles increased the probability of energy deposition in nanotargets, especially for high energy deposition, within
Databáze: OpenAIRE
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